Research

Evolution of adaptive variation

Adaptive variation is an evolutionary strategy where an organism confronts the environmental uncertainty generating phenotypic diversity either at the temporal scale in the individual or at the population scale between individuals. We want to identify the evolutionary conditions that allow for the emergence and persistence of this phenomenon.

La variación adaptativa es una estrategia evolutiva donde un organismo enfrenta la incertidumbre del ambiente generando diversidad fenotípica tanto a nivel temporal en el individuo como a nivel poblacional entre individuos. Queremos identificar las condiciones evolutivas que permiten la aparición y persistencia de este fenómeno.

Gómez-Schiavon & Buchler (2019). Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise. PLoS Computational Biology 15(10): e1007364. doi: 10.1371/journal.pcbi.1007364 (bioRxiv preprint. doi: 10.1101/072199)

Evolution of homeostasis

Homeostasis is a fundamental characteristic of many biological systems that allow to keep a variable of interest within its functional value regardless of environmental perturbations. Our objective is to identify and characterize mechanisms of homeostatic control generated by in silico evolution.

La homeostasis es una característica fundamental de muchos sistemas biológicos que permite mantener una variable de interés en su valor funcional frente a perturbaciones ambientales. Nuestro objetivo es identificar y caracterizar mecanismos de control homeostático producidos por evolución in silico.

Gómez-Schiavon & El-samad (2020). CoRa –A general approach for quantifying biological feedback control. bioRxiv. doi: 10.1101/2020.10.09.334078

Chevalier & Gómez-Schiavon et al. (2019). Design and analysis of a Proportional-Integral-Derivative controller with biological molecules. Cell Systems, 9, 338–353. doi: 10.1016/j.cels.2019.08.010 (bioRxiv preprint. doi: 10.1101/303545)