{"id":9,"date":"2021-01-29T17:52:35","date_gmt":"2021-01-29T17:52:35","guid":{"rendered":"http:\/\/mgschiavon.org\/?page_id=9"},"modified":"2026-01-13T17:48:41","modified_gmt":"2026-01-13T23:48:41","slug":"research","status":"publish","type":"page","link":"https:\/\/mgschiavon.org\/?page_id=9","title":{"rendered":"Research"},"content":{"rendered":"\n
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Evolution of homeostasis<\/strong><\/h4>\n\n\n\n

Homeostasis is a fundamental characteristic of many biological systems that allow to keep a variable of interest within its functional value regardless of environmental perturbations. Our objective is to identify and characterize mechanisms of homeostatic control generated by in silico<\/em> evolution.<\/p>\n<\/div>\n\n\n\n

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Evoluci\u00f3n de la homeostasis<\/strong><\/h4>\n\n\n\n

La homeostasis es una caracter\u00edstica fundamental de muchos sistemas biol\u00f3gicos que permite mantener una variable de inter\u00e9s en su valor funcional frente a perturbaciones ambientales. Nuestro objetivo es identificar y caracterizar mecanismos de control homeost\u00e1tico producidos por evoluci\u00f3n in silico<\/em>.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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G\u00f3mez-Schiavon & El-samad (2022<\/em>). CoRa \u2013A general approach for quantifying biological feedback control. PNAS 119(36):e2206825119.<\/em><\/mark>
doi: 10.1073\/pnas.2206825119<\/a><\/small><\/mark> (bioRxiv preprint.<\/em> doi:  <\/small><\/mark>10.1101\/2020.10.09.334078<\/a>)<\/small><\/mark><\/p>\n\n\n\n

Chevalier & G\u00f3mez-Schiavon et al.<\/em><\/strong> (2019<\/strong>). Design and analysis of a Proportional-Integral-Derivative controller with biological molecules. Cell Systems, 9, 338\u2013353.<\/em> <\/small>doi: 10.1016\/j.cels.2019.08.010<\/a> (bioRxiv preprint.<\/em> doi: 10.1101\/303545<\/a>)<\/small><\/mark><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

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Evolution of adaptive variation<\/strong>
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Adaptive variation is an evolutionary strategy where an organism confronts the environmental uncertainty generating phenotypic diversity either at the temporal scale in the individual or at the population scale between individuals. We want to identify the evolutionary conditions that allow for the emergence and persistence of this phenomenon.<\/p>\n<\/div>\n\n\n\n

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Evoluci\u00f3n de la variaci\u00f3n adaptativa<\/strong><\/h4>\n\n\n\n

La variaci\u00f3n adaptativa es una estrategia evolutiva donde un organismo enfrenta la incertidumbre del ambiente generando diversidad fenot\u00edpica tanto a nivel temporal en el individuo como a nivel poblacional entre individuos. Queremos identificar las condiciones evolutivas que permiten la aparici\u00f3n y persistencia de este fen\u00f3meno.<\/p>\n<\/div>\n<\/div>\n\n\n\n

Hern\u00e1ndez\u2011Garc\u00eda, M.E., G\u00f3mez\u2011Schiavon, M.<\/strong>, & Vel\u00e1zquez\u2011Castro, J. (2025). Stability analysis under intrinsic fluctuations: a second\u2011moment perspective of gene regulatory networks. Physical Biology, 22<\/strong> 066001<\/em>. doi:10.1088\/1478-3975\/ae0b22<\/a><\/mark><\/p>\n\n\n\n

Hern\u00e1ndez\u2011Garc\u00eda, M.E.<\/strong>, G\u00f3mez\u2011Schiavon, M.<\/strong>, & Vel\u00e1zquez\u2011Castro, J. (2024<\/strong>). Extrinsic Fluctuations in the p53 Cycle. The Journal of Chemical Physics 161, no. 18 (November 8, 2024): 184103<\/em>.
doi: <\/small>10.1063\/5.0227728<\/a>(aRxiv preprint. <\/em>doi: <\/small><\/small>10.48550\/arXiv.2408.12107<\/a>)<\/mark><\/p>\n\n\n\n

G\u00f3mez-Schiavon & Buchler (2019). Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise. PLoS Computational Biology 15(10): e1007364<\/em>. doi: 10.1371\/journal.pcbi.1007364<\/a> (bioRxiv preprint. <\/em>doi: 10.1101\/072199<\/a>)<\/small><\/mark><\/p>\n","protected":false},"excerpt":{"rendered":"

Evolution of homeostasis Homeostasis is a fundamental characteristic of many biological systems that allow to keep a variable of interest within its functional value regardless of environmental perturbations. Our objective is to identify and characterize mechanisms of homeostatic control generated by in silico evolution. Evoluci\u00f3n de la homeostasis La homeostasis es una caracter\u00edstica fundamental de… Read More »Research<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mgschiavon.org\/index.php?rest_route=\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mgschiavon.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mgschiavon.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mgschiavon.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mgschiavon.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9"}],"version-history":[{"count":54,"href":"https:\/\/mgschiavon.org\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":760,"href":"https:\/\/mgschiavon.org\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions\/760"}],"wp:attachment":[{"href":"https:\/\/mgschiavon.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}